Process intensification is a significant market trend in biomanufacturing. Continuous liquid chromatography—a paradigm shift from traditional batch chromatography operation—is key to increasing manufacturing efficiency.
Read MoreKaren O’Loughlin
Process Engineer
San Diego, CA
Karen has played a pivotal role in several intricate commercial-scale manufacturing projects involving the retrofitting of facilities that produce monoclonal antibodies. Her primary goal is to assist clients in enhancing throughput, optimizing transfer pathways and clean-in-place circuits, replacing end-of-life equipment, and intensifying processes. With over 11 years of experience as a process engineer, Karen has spent 5 years working on the owner’s side, concentrating on the design and commissioning of Clean-In-Plan (CIP) systems and large-scale column packing method development. Additionally, her design expertise extends to low-pressure liquid chromatography, including in-line dilution and gradient elution, and Tangential Flow Ultrafiltration systems.
"I have always been extremely passionate about my work and I am always hungry for the next complex project. There is nothing more rewarding than designing a system on paper, agonizing over the three-dimensional details, starting up the system and then watching it produce life-saving treatments."
Karen utilizes her experience to facilitate the introduction of new processes into existing facilities, optimize current facilities, and design new ones. Her focus has centered on comprehending the implications of continuous processing, particularly continuous chromatography, and determining how to implement these technologies on a commercial scale within both new and existing facilities.