Oligonucleotides

Facilities Engineering, Architecture, Construction and Consulting

Revolutionize oligonucleotide manufacturing for life-changing therapies.

Capitalize on oligo market momentum.

As more drugs achieve FDA approval and demand increases, your industry is positioned for rapid expansion. But without an established industry standard for your production facility, navigating the transition from clinical to commercial scale is daunting.

How can CRB help you?

Leading oligo researchers and manufacturers come to us as a pioneering force guiding this industry in its commercial infancy. With decades of commercial manufacturing experience to draw from, our engineers devise creative, risk-based solutions for large-scale production based on similar technologies and extensive experience working with oligos in clinical development.

We have been actively involved in the development of oligos from the start. We are as invested as you are in designing efficient, effective and compliant oligo facilities to make these life-saving therapies more widely available.

Let’s envision the future of oligo manufacturing together.

Tell us about your project; we’ll make it a reality.

HORIZONS

Horizons: Life Sciences 2024 coming soon!

Make sure you’re one of the first to receive this exclusive report. Built on the insights of 500 industry professionals, this facility-focused report offers guidance to stay ahead in the rapidly evolving life sciences sector. Our subject matter experts examine how companies manage capital and operational spending in a challenging economic climate before exploring facility, equipment and process trends.

Download the Report

The Next Insights

View all Insights

What we do:

Pharmaceuticals

Active Pharmaceutical Ingredients

Animal Health

Aseptic + Sterile Products

Plasma-Derived Therapies

Oral Solid Dosage

RNA Therapies

Don’t decide between product quality and production efficiency.

You can have a more efficient, more sustainable, lower cost facility that produces the best quality pharmaceutical products for your patients. Get a customized, best-in-class solution from experts who possess extensive knowledge and experience in all aspects of pharma manufacturing.

Make APIs faster, cheaper and with less waste.

It’s not enough to build a functional bulk pharmaceuticals manufacturing facility; you must meet increasingly more rigorous safety and quality standards, while producing APIs quickly and efficiently. Get a solution for your new or existing facility to achieve your business aims, and most importantly, find opportunities to improve upon your process.

Reduce your animal health project timeline and lower capital costs with lead design and construction execution.

Animal health affects billions of people worldwide, so it’s vitally important that your products are effective and safe. How do you do that when the cost margin is low?

Mitigate the risks of your most complex aseptic processes.

Every component matters in aseptic processing—especially the people designing and building your facility. The safety and efficacy of your product rely on the coordination and interaction of personnel, equipment, facility and the product. Cleanliness and contamination control must be engineered and built in.

Plasma-derived therapies are more critical than ever.

Ramping up production to meet increasing demand is a monumental task due to the unique challenges of plasma-derived medicinal product production. The complex, time-consuming, and expensive manufacturing process makes the proper design of your plasma fractionation and purification facility more important than ever. The right facility design paves the way to lower operating costs and higher product yields, allowing you to maximize the return on every liter of plasma processed.

Patients are relying on your OSD drug product.

Because a well-designed process is central to your success, the right process solution is also unique to you. Whether you’re ready to enter the continuous manufacturing arena or you’re looking to achieve a wider range of capabilities with a more robust CM system, implement the process that’s best for your business.

Flexible RNA therapy facilities for a rapidly advancing sector.

Lead the way for this revolutionary technology with design and construction solutions that right-size your process, help you navigate a complex regulatory environment, and create a flexible facility that can adapt with the industry and your organization.