Veterinary Biological Production Facility Design

Veterinary Biological Production Facility Design

CRB was the prime consultant for the design of a production and administrative expansion to this existing veterinary biological production facility. The facility is used to manufacture bacterial and viral antigens in compliance with US and European Union regulatory requirements.

CRB’s responsibilities began with an initial feasibility study and continued through concept, detailed design, equipment procurement, and construction support. CRB was also responsible for system integration design through an automation subcontractor. The facility expansion is adjacent to existing commercial manufacturing operations so significant phasing and coordination were a critical component of the project’s success.

The expansion also included modifications to the existing facility infrastructure to meet current EMA requirements including a new central service area and upgrade to media prep and tissue culture lab. Facility flows, airlocking, and classification/pressure cascades for EMA compliance was a significant focus of the modifications.

The project scope included new fermentors, process vessels and DSP equipment, a new central services area, a new filling line and lyophilizer, new and relocated autoclaves, CIP skids, transfer panels and transfer piping.

Process utility systems included design of new RO and WFI generation, storage and distribution, ice harvester, pure steam generator, cooling tower, a continuous biowaste inactivation system designed for BL2 biowaste, and a neutralization skid designed to neutralize both killed biowaste and industrial waste.

Project Details


Boehringer Ingelheim Vetmedica, Inc.


St. Joseph, Missouri

Square Footage


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