Active Pharmaceutical Ingredient Pilot Plant Design + CM

CRB provided full architectural, engineering and construction management services to retrofit existing warehouse space into a cleanroom pilot plant for the chemical synthesis of active pharmaceutical ingredients.

CRB initially performed a basis-of-design study providing a +/-30% construction cost estimate for management approval and was subsequently awarded detailed design and full construction management services.

Project Highlights:

• The pilot plant renovation was approximately 7,000 square feet and capable of approximately 30KG production quantities.
• The area included two separate 200-liter reactor skids of hastelloy and glass lined steel.
• The pilot plant was also equipped with centrifugation, filter dryer and conical dryer unit operations.
• The entire pilot plant area was designed for solvents and hazardous materials.
• The pilot plant also included the addition of a process chiller, temperature control modules, vacuum pumps, scrubber and purified water system.