Active Pharmaceutical Ingredient Pilot Plant Design + CM

Active Pharmaceutical Ingredient Pilot Plant Design + CM

CRB provided full architectural, engineering and construction management services to retrofit existing warehouse space into a cleanroom pilot plant for the chemical synthesis of active pharmaceutical ingredients.

CRB initially performed a basis-of-design study providing a +/-30% construction cost estimate for management approval and was subsequently awarded detailed design and full construction management services.

Project Highlights:

  • The pilot plant renovation was approximately 7,000 square feet and capable of approximately 30KG production quantities.
  • The area included two separate 200-liter reactor skids of hastelloy and glass lined steel.
  • The pilot plant was also equipped with centrifugation, filter dryer and conical dryer unit operations.
  • The entire pilot plant area was designed for solvents and hazardous materials.
  • The pilot plant also included the addition of a process chiller, temperature control modules, vacuum pumps, scrubber and purified water system.

Project Details


Confidential Client


Western USA

Square Footage



$13 million

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