Biopharma lab microscope - DNA and cells

New ATMP facility sets sights on sustainability goals with ONEsolution approach

Umoja Biopharma, Inc., a preclinical stage oncology company, sees a different future for cancer treatment—a future that provides access to all cancer patients and alleviates the burdens of traditional treatment paths. Umoja leverages in vivo advanced immunotherapies to help the body fight solid cancer tumors through a next-generation cell and gene therapy approach.

As Umoja’s pipeline development grew and advanced, it outgrew its existing laboratory space. The team identified a need for a larger, permanent facility to call home for development and clinical manufacturing.

CRB is providing end-to-end project delivery through our ONEsolution method to design and build Umoja’s new approximately 150,000-square-foot facility in Louisville, Colorado. The project will convert an existing core and shell building into a highly flexible and scalable development and manufacturing site with laboratory, office, and warehouse space. The facility will also boast a new second floor with mountain views. As is the case when converting most existing spaces into a lab, the MEP systems (mechanical, electrical, and plumbing) must be rightsized to answer the high demands required by clinical manufacturing.

Purpose and objectives defined with a project charter

From the project start, CRB worked to understand and align on stakeholder goals and drivers. The team developed a comprehensive project charter that laid out the project’s business case, conditions of satisfaction and major milestones.

Some of the key objectives that came to light during the project chartering phase were product flexibility, production scalability and sustainability.

Energy and sustainability goals

While collaborating during one of the early project chartering sessions, we were able to zero in on Umoja’s deeply held social and environmental values.

As a result, the clinical manufacturing facility’s design will focus on features to integrate LEED criteria, become WELL Silver certified, promote an inclusive design, and a future goal of zero carbon emissions to support the company’s virtues. Even though the facility is not yet finished, the Umoja team—along with their extended CRB team—has already begun serving their new, local community through volunteer outreach projects.

Project Details


Umoja Biopharma, Inc.


Louisville, Co

Square Footage


“Umoja comes from the Swahili word for unity that reinforces its focus on bringing separate components together to create a powerful result, whether that is in the people who make up the company or the platform technologies that make up our therapeutic process. This value guides us each day to meet the challenge of living up to our best selves and staying focused on inclusion.”

Target value delivery

Target value delivery, a management practice used during design and construction, is helping us deliver this project within a fixed budget, while meeting Umoja’s operational needs and values.

With CRB’s ONEsolution delivery method, the entire team is on board from the beginning. This means that our construction team members and key trade partners can provide their feedback on the estimate while it can still make an impact. This is especially important in today’s circumstances, when material prices and lead times are a concern.

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